Drying Up the Root – Science Links
In my video “Drying Up the Root – LCHF and the Fasting Cure”, I talked about a lot of very different conditions that could be pictured as branches of the same tree, with a common underlying root, insulin resistance and chronically high insulin levels (what scientists call “hyperinsulinemia”).
In this post, I want to give you several references to solid sources of information on those many connections.
Banting Lecture 1988. Role of Insulin Resistance in Human Disease
by Gerald M. Reaven
This is the paper that got the attention of the research community, it’s important because it connects insulin resistance and hyperinsulinemia as the root of all the other diseases in this syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/3056758 – reference
http://www.fcfar.unesp.br/arquivos/493291.pdf – full file in pdf format
The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.
by Norman M. Kaplan
Another of the important early papers to define Insulin Resistance Syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/2662932 – reference
http://www.phys.mcw.edu/documents/Special%20Topics%20Neuroscience%20Fall%202008/documents/Kaplan-NM-1989-Group-10.pdf – full file in pdf format
Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
http://atvb.ahajournals.org/content/24/2/e13.long
Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
http://circ.ahajournals.org/content/112/17/2735.full
American College of Endocrinology Position Statement on the Insulin Resistance Syndrome
This is a very clear statement of the insulin problem and it’s many relationships and connections.
Hyperinsulinemic diseases of civilization: more than just Syndrome X
– this is a highly technical article that covers this “tree” in great detail – from the famous illnesses that I covered, to a host of eye sight problems, skin problems, hormone problems that cause early periods in girls and early balding in men.
http://www.direct-ms.org/sites/default/files/Hyperinsulinemia.pdf
Insulin Resistance and Hyperinsulinemia – Is hyperinsulinemia the cart or the horse?
This article shows the vicious “which came first the chicken or the egg”
http://care.diabetesjournals.org/content/31/Supplement_2/S262.full
A Comprehensive Review on Metabolic Syndrome
Very good, very deep article.
http://www.hindawi.com/journals/crp/2014/943162/
Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome
The history of discovery of the relationships between the branches of this tree of metabolic diseases.
http://www.sciencedirect.com/science/article/pii/S1550413104000075
Insulin Resistance, Type 2 Diabetes Mellitus, and Cardiovascular Disease – The End of the Beginning
http://circ.ahajournals.org/content/112/20/3030.full
Insulin Resistance and Coronary Heart Disease in Nondiabetic Individuals
http://atvb.ahajournals.org/content/32/8/1754.long
Insulin Resistance -Comprehensive article from Medscape:
http://emedicine.medscape.com/article/122501-overview
A Comprehensive Review on Metabolic Syndrome
http://www.hindawi.com/journals/crp/2014/943162/
INFLAMMATION
Obesity, Inflammation, and Insulin Resistance – A Mini-Review
http://www.karger.com/Article/FullText/212758
INFLAMMATION
Obesity and the role of adipose tissue in inflammation and metabolism
http://ajcn.nutrition.org/content/83/2/461S.full
INFLAMMATION
Adipose Tissue, Inflammation, and Cardiovascular Disease
http://circres.ahajournals.org/content/96/9/939.full
THICKENING BLOOD
REDUCED ABILITY TO BREAK UP CLOTS
Clustering of Procoagulation, Inflammation, and Fibrinolysis Variables with Metabolic Factors in Insulin Resistance Syndrome
http://aje.oxfordjournals.org/content/152/10/897.full
JOINT PAIN
Obesity and psoriatic arthritis: from pathogenesis to clinical outcome and management
http://rheumatology.oxfordjournals.org/content/52/1/62.full
CANCER
Metabolic syndrome, hyperinsulinemia, and colon cancer: a review
http://ajcn.nutrition.org/content/86/3/836S.full
EATING LESS TO REVERSE TYPE 2 DIABETES
Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause
http://link.springer.com/content/pdf/10.1007%2Fs00125-008-1116-7.pdf
EATING LESS TO REVERSE TYPE 2 DIABETES
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/pdf/125_2011_Article_2204.pdf
EATING LESS TO REVERSE TYPE 2 DIABETES
Type 2 Diabetes: Etiology and Reversibility
http://www.medscape.com/viewarticle/781719_1
EATING LESS TO REVERSE TYPE 2 DIABETES
Banting Memorial Lecture 2012 Reversing the twin cycles of Type 2 diabetes
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593165/
BLOOD FAT PROBLEMS
High Ratio of Triglycerides to HDL-Cholesterol Predicts Extensive Coronary Disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664115/
BLOOD FAT PROBLEMS
Fasting Triglycerides, High-Density Lipoprotein, and Risk of Myocardial Infarction
http://circ.ahajournals.org/content/96/8/2520.full
LIVER FAT AND JUNK FOOD
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
http://ajcn.nutrition.org/content/96/4/727.long
AS WE GET OLDER, WE GET MORE INSULIN PROBLEMS
Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals
http://press.endocrine.org/doi/full/10.1210/jcem.82.12.4457
AS WE GET OLDER, WE GET MORE INSULIN PROBLEMS
Effects of Ageing on Insulin Secretion and Action
http://www.karger.com/Article/FullText/71233
HISTORY OF FASTING
Fasting: The History, Pathophysiology and Complications
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274154/pdf/westjmed00207-0055.pdf
FASTING
The effect on health of alternate day calorie restriction: Eating less and more than needed on alternate days prolongs life
James B. Johnson
http://www.johnsonupdaydowndaydiet.com/pdf/ADCR%20JBJ%20MH.pdf
FASTING
Alternate-day fasting and chronic disease prevention: a review of human and animal trials
http://ajcn.nutrition.org/content/86/1/7.full
EATING LESS TO LIVE LONGER
Calorie restriction and aging: review of the literature and implications for studies in humans
http://ajcn.nutrition.org/content/78/3/361.full
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
http://www.sciencedirect.com/science/article/pii/S1550413112001891
Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009–2010)
http://cebp.aacrjournals.org/content/24/5/783.abstract
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomised trial in young overweight women
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
The health pros and cons of continuous versus intermittent calorie restriction: More questions than answers
https://usu.instructure.com/courses/361089/files/55675248/download?wrap=1
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
http://www.pnas.org/content/100/10/6216.full
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Great video. I LOVE your outdoor videos. Always great info but the settings makes them even more enjoyable. One of the main reasons that I want to lose weight and get healthier is so that I can get back to the woods. I used to love hiking and camping in GA, NC and TN. Need to get back there!! Did I say thank you?? Well,. THANK YOU!