Drying Up the Root – Science Links – Butter Makes Your Pants Fall Off

Drying Up the Root – Science Links

In my video “Drying Up the Root – LCHF and the Fasting Cure”, I talked about a lot of very different conditions that could be pictured as branches of the same tree, with a common underlying root, insulin resistance and chronically high insulin levels (what scientists call “hyperinsulinemia”).

In this post, I want to give you several references to solid sources of information on those many connections.

Banting Lecture 1988. Role of Insulin Resistance in Human Disease

by Gerald M. Reaven
This is the paper that got the attention of the research community, it’s important because it connects insulin resistance and hyperinsulinemia as the root of all the other diseases in this syndrome.

http://www.ncbi.nlm.nih.gov/pubmed/3056758 – reference
http://www.fcfar.unesp.br/arquivos/493291.pdf – full file in pdf format

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.

by Norman M. Kaplan

Another of the important early papers to define Insulin Resistance Syndrome.

http://www.ncbi.nlm.nih.gov/pubmed/2662932 – reference
http://www.phys.mcw.edu/documents/Special%20Topics%20Neuroscience%20Fall%202008/documents/Kaplan-NM-1989-Group-10.pdf – full file in pdf format

Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition

http://atvb.ahajournals.org/content/24/2/e13.long

Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement

http://circ.ahajournals.org/content/112/17/2735.full

American College of Endocrinology Position Statement on the Insulin Resistance Syndrome

This is a very clear statement of the insulin problem and it’s many relationships and connections.

https://www.aace.com/files/american-college-of-endocrinology-position-statement-on-the-insulin-resistance-syndrome.pdf

Hyperinsulinemic diseases of civilization: more than just Syndrome X

– this is a highly technical article that covers this “tree” in great detail – from the famous illnesses that I covered, to a host of eye sight problems, skin problems, hormone problems that cause early periods in girls and early balding in men.

http://www.direct-ms.org/sites/default/files/Hyperinsulinemia.pdf

Insulin Resistance and Hyperinsulinemia – Is hyperinsulinemia the cart or the horse?

This article shows the vicious “which came first the chicken or the egg”

http://care.diabetesjournals.org/content/31/Supplement_2/S262.full

A Comprehensive Review on Metabolic Syndrome

Very good, very deep article.

http://www.hindawi.com/journals/crp/2014/943162/

Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome

The history of discovery of the relationships between the branches of this tree of metabolic diseases.

http://www.sciencedirect.com/science/article/pii/S1550413104000075

Insulin Resistance, Type 2 Diabetes Mellitus, and Cardiovascular Disease – The End of the Beginning

http://circ.ahajournals.org/content/112/20/3030.full

INFLAMMATION

Obesity, Inflammation, and Insulin Resistance – A Mini-Review

http://www.karger.com/Article/FullText/212758

INFLAMMATION

Obesity and the role of adipose tissue in inflammation and metabolism

http://ajcn.nutrition.org/content/83/2/461S.full

INFLAMMATION

Adipose Tissue, Inflammation, and Cardiovascular Disease

http://circres.ahajournals.org/content/96/9/939.full

THICKENING BLOOD
REDUCED ABILITY TO BREAK UP CLOTS

Clustering of Procoagulation, Inflammation, and Fibrinolysis Variables with Metabolic Factors in Insulin Resistance Syndrome

http://aje.oxfordjournals.org/content/152/10/897.full

JOINT PAIN

Obesity and psoriatic arthritis: from pathogenesis to clinical outcome and management

http://rheumatology.oxfordjournals.org/content/52/1/62.full

CANCER

Metabolic syndrome, hyperinsulinemia, and colon cancer: a review

http://ajcn.nutrition.org/content/86/3/836S.full

EATING LESS TO REVERSE TYPE 2 DIABETES

Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause

http://www.practicaldiabetes.com/SpringboardWebApp/userfiles/espdi/file/November%202011/Ldr%20Taylor_PD%202-col.pdf

http://link.springer.com/content/pdf/10.1007%2Fs00125-008-1116-7.pdf

EATING LESS TO REVERSE TYPE 2 DIABETES

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168743/pdf/125_2011_Article_2204.pdf

EATING LESS TO REVERSE TYPE 2 DIABETES

Type 2 Diabetes: Etiology and Reversibility

http://www.medscape.com/viewarticle/781719_1

EATING LESS TO REVERSE TYPE 2 DIABETES

Banting Memorial Lecture 2012 Reversing the twin cycles of Type 2 diabetes

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593165/

BLOOD FAT PROBLEMS

High Ratio of Triglycerides to HDL-Cholesterol Predicts Extensive Coronary Disease

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664115/

BLOOD FAT PROBLEMS

Fasting Triglycerides, High-Density Lipoprotein, and Risk of Myocardial Infarction

http://circ.ahajournals.org/content/96/8/2520.full

LIVER FAT AND JUNK FOOD

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

http://ajcn.nutrition.org/content/96/4/727.long

AS WE GET OLDER, WE GET MORE INSULIN PROBLEMS

Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals

http://press.endocrine.org/doi/full/10.1210/jcem.82.12.4457

AS WE GET OLDER, WE GET MORE INSULIN PROBLEMS

Effects of Ageing on Insulin Secretion and Action

http://www.karger.com/Article/FullText/71233

HISTORY OF FASTING

Fasting: The History, Pathophysiology and Complications

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1274154/pdf/westjmed00207-0055.pdf

FASTING

The effect on health of alternate day calorie restriction: Eating less and more than needed on alternate days prolongs life

James B. Johnson

http://www.johnsonupdaydowndaydiet.com/pdf/ADCR%20JBJ%20MH.pdf

FASTING

Alternate-day fasting and chronic disease prevention: a review of human and animal trials

http://ajcn.nutrition.org/content/86/1/7.full

EATING LESS TO LIVE LONGER

Calorie restriction and aging: review of the literature and implications for studies in humans

http://ajcn.nutrition.org/content/78/3/361.full

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

http://www.sciencedirect.com/science/article/pii/S1550413112001891

Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES (2009–2010)

http://cebp.aacrjournals.org/content/24/5/783.abstract

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomised trial in young overweight women

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/

The health pros and cons of continuous versus intermittent calorie restriction: More questions than answers

https://usu.instructure.com/courses/361089/files/55675248/download?wrap=1

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

http://www.pnas.org/content/100/10/6216.full

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